GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs10540 | 1 | rs12794284 | chr11:477623 | RNH1 | chr11:494512-507273:- | -0.18 | -4.29 | 1.96E-5 | Body mass index |
| BRCA | cis | rs4765219 | 1 | rs12809125 | chr12:124407991 | DNAH10 | chr12:124247042-124420265:+ | 0.25 | 6.43 | 1.87E-10 | Waist-to-hip ratio adjusted for body mass index |
| BRCA | cis | rs12579753 | 1 | rs12811607 | chr12:82233619 | PPFIA2 | chr12:81652880-82153109:- | 0.13 | 3.4 | 0.000688 | Resting heart rate |
| BRCA | cis | rs1322512 | 1 | rs1282551 | chr6:153009944 | SYNE1 | chr6:152442823-152958534:- | 0.09 | 3.56 | 0.000394 | Tonometry |
| BRCA | cis | rs1322512 | 1 | rs1282551 | chr6:153009944 | VIP | chr6:153071933-153080898:+ | -0.13 | -4.22 | 2.68E-5 | Tonometry |
| BRCA | cis | rs12579753 | 1 | rs12827923 | chr12:82242067 | PPFIA2 | chr12:81652880-82153109:- | 0.13 | 3.41 | 0.00068 | Resting heart rate |
| BRCA | cis | rs7973719 | 1 | rs12828040 | chr12:7326541 | PEX5 | chr12:7341759-7371167:+ | 0.21 | 6.09 | 1.56E-9 | IgG glycosylation |
| BRCA | cis | rs7973719 | 1 | rs12828421 | chr12:7335217 | PEX5 | chr12:7341759-7371167:+ | -0.22 | -6.38 | 2.66E-10 | IgG glycosylation |
| BRCA | cis | rs12579753 | 1 | rs12830268 | chr12:82233627 | PPFIA2 | chr12:81652880-82153109:- | 0.13 | 3.4 | 0.000688 | Resting heart rate |
| BRCA | cis | rs17594362 | 1 | rs12866839 | chr13:42152254 | NAA16 | chr13:41885341-41951166:+ | 0.15 | 3.61 | 0.000322 | Multiple sclerosis |
| BRCA | cis | rs7494379 | 1 | rs12888114 | chr14:53401261 | STYX | chr14:53196883-53241703:+ | 0.12 | 3.46 | 0.000559 | Glaucoma (primary angle closure) |
| BRCA | cis | rs11622475 | 1 | rs12889168 | chr14:104481957 | TDRD9 | chr14:104394817-104519002:+ | 0.42 | 10.62 | 4.02E-25 | Bipolar disorder |
| BRCA | cis | rs910316 | 1 | rs12889472 | chr14:75543979 | EIF2B2 | chr14:75469612-75476292:+ | 0.18 | 4.9 | 1.12E-6 | Height |
| BRCA | cis | rs910316 | 1 | rs12889472 | chr14:75543979 | MLH3 | chr14:75480467-75518235:- | 0.2 | 6.17 | 9.77E-10 | Height |
| BRCA | cis | rs2404602 | 1 | rs12898430 | chr15:76874923 | SCAPER | chr15:76640529-77197744:- | -0.19 | -6.75 | 2.4E-11 | Blood metabolite levels |